SCHEMBL27361709

SCHEMBL27361709

CCC(CCn1ccc(N)c1C#N)c1ccc(C(=O)OOC(C)(C)C)cc1

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
TSHR P16473 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HDAC8 Q9BY41 1/20 0.30
HDAC6 Q9UBN7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8569504 0.90 NR3C2 (0.34) HDAC8HDAC6
SCHEMBL8564883 0.79 CA12 (0.34)
SCHEMBL27378174 0.78 ALDH1A1 (0.39) ALDH1A1TSHRHSD17B10TDP1
SCHEMBL27378170 0.74 TSHR (0.49) ALDH1A1TSHRHSD17B10TDP1HDAC8
SCHEMBL8562850 0.70 CYP4A11 (0.35) HDAC8HDAC6
SCHEMBL8565003 0.68 CA12 (0.36)
Hydrochloric Acid SCHEMBL27720954 0.67 TSHR (0.53) ALDH1A1TSHRHSD17B10TDP1HDAC8
SCHEMBL8567809 0.67 CA12 (0.36)
SCHEMBL8567806 0.67 CA12 (0.36)
SCHEMBL28859873 0.65 ALDH1A1 (0.53) ALDH1A1TSHRHSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1070402-A The pyrimidine derivatives of condensation EISAI CO LTD (JP) 1993-03-31 CN disclosed