Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16418620 | 0.93 | HDAC8 (0.43) | HDAC8ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL22704137 | 0.78 | ALDH1A1 (0.38) | HDAC8ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL21064117 | 0.75 | DDB1 (0.55) | LMNASMN1; SMN2MAPTDDB1CRBN | |
| SCHEMBL25041354 | 0.74 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2MAPTCRHBP | |
| SCHEMBL5608474 | 0.74 | HDAC8 (0.59) | HDAC8ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL19697062 | 0.73 | POLB (0.43) | ALDH1A1LMNASMN1; SMN2MAPTCRHBP | |
| SCHEMBL13663589 | 0.72 | HDAC8 (0.54) | HDAC8ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL13801923 | 0.72 | HDAC8 (0.57) | HDAC8ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL16418618 | 0.72 | TSHR (0.41) | ALDH1A1LMNAMAPTKDM4EPOLB | |
| SCHEMBL24506805 | 0.71 | MALT1 (0.43) | HDAC8LMNAKDM4EPOLBEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054807-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND TDP-43 MODULATORS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-14 | — | — | WO | disclosed |