Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608680 | 0.90 | ALDH1A1 (0.54) | HDAC8ALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL13801923 | 0.84 | HDAC8 (0.57) | HDAC8ALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL82947 | 0.82 | BRD4 (0.48) | HDAC8ALDH1A1KDM4EPOLBRAPGEF4 | |
| SCHEMBL2361893 | 0.82 | KDM4E (0.59) | HDAC8ALDH1A1KDM4EPOLBL3MBTL1 | |
| Hydrochloric Acid SCHEMBL69124 | 0.81 | BRD4 (0.47) | HDAC8ALDH1A1KDM4EPOLBRAPGEF4 | |
| SCHEMBL1341748 | 0.80 | KDM4E (0.56) | HDAC8ALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL13663589 | 0.80 | HDAC8 (0.54) | HDAC8ALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL11847765 | 0.80 | ALDH1A1 (0.46) | HDAC8ALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL3674808 | 0.79 | NPC1 (0.51) | HDAC8ALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL18010743 | 0.79 | ALDH1A1 (0.49) | HDAC8ALDH1A1KDM4EPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1354887-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1097158-B1 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1354887-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | Massachusetts Insitute of Technology (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1097158-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002887-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-01-20 | — | — | WO | disclosed |