Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ESRRB | O95718 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27364621 | 0.97 | MAPT (0.47) | MAPTNPSR1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL24834707 | 0.94 | MAPT (0.47) | MAPTNPSR1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL12082219 | 0.90 | MAPT (0.51) | MAPTNPSR1KMT2AMEN1HTR7 | |
| SCHEMBL27364407 | 0.87 | EBP (0.44) | MAPTNPSR1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22542091 | 0.87 | MAPT (0.51) | MAPTNPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3666881 | 0.86 | SLC6A2 (0.53) | KMT2AKDM4EHTR7GAADRD2 | |
| SCHEMBL27364131 | 0.86 | DRD3 (0.43) | MAPTCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL20372819 | 0.86 | MAPT (0.51) | MAPTNPSR1ALDH1A1POLBHTR7 | |
| SCHEMBL15499062 | 0.84 | MAPT (0.47) | MAPTNPSR1KMT2AMEN1HTR7 | |
| SCHEMBL3665444 | 0.84 | DRD2 (0.60) | KMT2AMEN1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |