Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517601 | 0.85 | HTR3A (0.51) | TNKSHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL27364325 | 0.83 | GRIN2D (0.50) | TNKSHTR3AHSD17B10ALDH1A1CYP2D6 | |
| SCHEMBL4527814 | 0.79 | HTR3A (0.46) | TNKSHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL18436686 | 0.77 | OGA (0.46) | HSD17B10ALDH1A1CYP2D6TSHRHPGD | |
| SCHEMBL1432869 | 0.76 | MAPT (0.51) | ALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL22932059 | 0.75 | CYP11B1 (0.53) | HSD17B10ALDH1A1CYP2D6TSHRHPGD | |
| SCHEMBL1432610 | 0.74 | MAPT (0.53) | HSD17B10ALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL14996516 | 0.74 | HSD17B10 (0.69) | HSD17B10ALDH1A1CYP2D6TSHRHPGD | |
| SCHEMBL27366338 | 0.73 | CYP3A4 (0.42) | HSD17B10ALDH1A1CYP2D6TSHRHPGD | |
| SCHEMBL31382372 | 0.73 | UBE2T (0.37) | HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |