Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363463 | 0.74 | KCNH2 (0.41) | MERTKAXLAURKARETMET | |
| SCHEMBL27366890 | 0.74 | DRD2 (0.46) | MERTKRETCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL27367383 | 0.74 | CACNA2D1 (0.39) | MERTKAXLAURKARETMET | |
| SCHEMBL3413013 | 0.73 | PLD1 (0.53) | CYP3A4CYP2C9HPGDMEN1ALDH1A1 | |
| SCHEMBL27366339 | 0.73 | PDE10A (0.47) | MERTKCACNA2D1CACNA1BCACNB1CHRM4 | |
| SCHEMBL27363571 | 0.73 | GPR119 (0.45) | MERTKAXLAURKARETMET | |
| SCHEMBL27363476 | 0.73 | TNKS (0.41) | CYP3A4CYP2C9TSHRCYP2D6HPGD | |
| SCHEMBL23875271 | 0.72 | HPGDS (0.46) | HPGDALDH1A1KMT2ASMN1; SMN2CACNA2D1 | |
| SCHEMBL27367212 | 0.72 | PDE10A (0.42) | RETDGAT1CHRM4 | |
| SCHEMBL27363630 | 0.71 | CHRM4 (0.43) | RETCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |