Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | DRD5 | P21918 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27366337 | 0.95 | PDE10A (0.43) | GPR119DRD2DRD3DRD1DRD5 | |
| SCHEMBL27363705 | 0.89 | DRD2 (0.47) | GPR119DRD2DRD3DRD1DRD5 | |
| SCHEMBL27362867 | 0.89 | DRD2 (0.50) | GPR119DRD2DRD3DRD1DRD5 | |
| SCHEMBL27363567 | 0.86 | DRD2 (0.47) | GPR119DRD2DRD3DRD1DRD5 | |
| SCHEMBL27367212 | 0.85 | PDE10A (0.42) | GPR119DRD2DRD3DRD1DRD5 | |
| SCHEMBL27363063 | 0.84 | KCNH2 (0.36) | GPR119KCNH2TYRO3OPRM1OPRD1 | |
| SCHEMBL27364325 | 0.83 | GRIN2D (0.50) | GPR119DRD2DRD3DRD1DRD5 | |
| SCHEMBL27364407 | 0.81 | EBP (0.44) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL14853100 | 0.81 | PDE10A (0.48) | GPR119DRD2DRD3DRD1DRD5 | |
| SCHEMBL14853102 | 0.81 | DRD2 (0.51) | GPR119DRD2DRD3DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |