Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363067 | 0.88 | GPR119 (0.41) | KCNH2GPR119CYP3A4TLR9TLR8 | |
| SCHEMBL27363464 | 0.88 | CASP1 (0.42) | KCNH2GPR119CYP3A4CACNA2D1CACNA1B | |
| SCHEMBL27363461 | 0.85 | KCNH2 (0.42) | KCNH2GPR119CYP3A4CYP2D6MEN1 | |
| SCHEMBL27363571 | 0.84 | GPR119 (0.45) | KCNH2GPR119TLR9TLR8TLR7 | |
| SCHEMBL25510868 | 0.82 | CYP3A4 (0.45) | GPR119CYP3A4CYP2D6TSHRMEN1 | |
| SCHEMBL27366337 | 0.79 | PDE10A (0.43) | KCNH2GPR119TYRO3OPRM1OPRD1 | |
| SCHEMBL27364407 | 0.79 | EBP (0.44) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL15759139 | 0.78 | CHRM5 (0.46) | KCNH2GPR119CASP1CASP4CASP5 | |
| SCHEMBL27362872 | 0.77 | ACHE (0.47) | KCNH2GPR119TSHRALDH1A1CASP1 | |
| SCHEMBL14996488 | 0.77 | NCF1 (0.43) | KCNH2CYP2D6TSHROPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |