SCHEMBL2736396

SCHEMBL2736396

c1ccc2c(c1)Oc1ccccc1C2CCCC1c2ccccc2Oc2ccccc21

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
GRM2 Q14416 2/20 0.44
GRM3 Q14832 1/20 0.44
ATM Q13315 1/20 0.44
KCNA3 P22001 1/20 0.43
KMT2A Q03164 5/20 0.43
MEN1 O00255 4/20 0.43
MAPT P10636 2/20 0.43
LMNA P02545 2/20 0.43
USP2 O75604 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.41
HTR2A P28223 1/20 0.41
HRH1 P35367 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6402895 0.88 MAOA (0.50) MAOAMAOBCYP1A2CYP2D6GRM2
SCHEMBL28633848 0.88 KMT2A (0.50) MAOAMAOBCYP1A2CYP2D6GRM2
SCHEMBL6125509 0.86 KMT2A (0.51) MAOAMAOBCYP1A2CYP2D6KMT2A
SCHEMBL7595514 0.86 CYP1A2 (0.45) MAOAMAOBCYP1A2CYP2D6GRM2
SCHEMBL17162934 0.85 HTR2A (0.50) MAOAMAOBCYP1A2CYP2D6GRM2
SCHEMBL21436988 0.85 GRM8 (0.51) MAOAMAOBCYP1A2CYP2D6KMT2A
SCHEMBL11994168 0.83 CYP1A2 (0.50) MAOAMAOBCYP1A2CYP2D6GRM2
SCHEMBL11615204 0.83 HTR2A (0.55) MAOAMAOBCYP1A2CYP2D6GRM2
SCHEMBL6731123 0.83 MAOA (0.54) MAOAMAOBCYP1A2CYP2D6GRM2
SCHEMBL8101911 0.78 L3MBTL1 (0.47) MAOAMAOBCYP1A2CYP2D6GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8766242-B2 Aromatic chalcogen compounds and their use E I DU PONT DE NEMOURS AND COMPANY (US) 2014-07-01 US disclosed
US-20120068166-A1 AROMATIC CHALCOGEN COMPOUNDS AND THEIR USE E. I. DU PONT DE NEMOURS AND COMPANY (US) 2012-03-22 US disclosed
US-8089064-B2 Aromatic chalcogen compounds and their use E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-01-03 US disclosed
US-20090121627-A1 AROMATIC CHALCOGEN COMPOUNDS AND THEIR USE E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-14 US disclosed
US-7504769-B2 Aromatic chalcogen compounds and their use E. I. DU PONT DE NEMOURS + COMPANY (US) 2009-03-17 US disclosed