SCHEMBL27366041

SCHEMBL27366041

Cn1cc(-c2cc3c(Oc4ccc(NC(=O)c5cccn(-c6ccc(F)cc6)c5=O)cc4)ncnc3o2)cn1

nearest known ligand 0.73

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AXL P30530 20/20 0.73
MERTK Q12866 19/20 0.73
TYRO3 Q06418 4/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27366035 0.89 MERTK (0.68) AXLMERTKTYRO3
SCHEMBL27366453 0.85 AXL (0.66) AXLMERTKTYRO3
SCHEMBL30883353 0.85 MERTK (0.84) AXLMERTKTYRO3
SCHEMBL27367825 0.85 MERTK (0.84) AXLMERTKTYRO3
SCHEMBL27366545 0.83 MERTK (0.53) AXLMERTKTYRO3
SCHEMBL27365775 0.83 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL27365857 0.83 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL31512153 0.82 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL31512151 0.82 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL27366042 0.82 MERTK (1.00) AXLMERTKTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed