SCHEMBL27366545

SCHEMBL27366545

Cn1cc(-c2cc3c(Oc4ccc(NC(=O)c5cccn(C6CCCCC6)c5=O)cc4)ncnc3o2)cn1

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 20/20 0.53
AXL P30530 18/20 0.53
TYRO3 Q06418 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27366041 0.83 AXL (0.73) MERTKAXLTYRO3
SCHEMBL27366538 0.83 MERTK (0.75) MERTKAXLTYRO3
SCHEMBL27366539 0.81 MERTK (0.76) MERTKAXLTYRO3
SCHEMBL27366306 0.72 MERTK (0.81) MERTKAXLTYRO3
SCHEMBL27366035 0.72 MERTK (0.68) MERTKAXLTYRO3
SCHEMBL27366449 0.71 MERTK (0.81) MERTKAXLTYRO3
SCHEMBL27367825 0.70 MERTK (0.84) MERTKAXLTYRO3
SCHEMBL30883353 0.70 MERTK (0.84) MERTKAXLTYRO3
SCHEMBL27366195 0.69 MERTK (0.89) MERTKAXLTYRO3
SCHEMBL23900688 0.69 CSF1R (0.64)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed