SCHEMBL27366035

SCHEMBL27366035

O=C(Nc1ccc(Oc2ncnc3oc(-c4ccccc4)cc23)cc1)c1cccn(-c2ccc(F)cc2)c1=O

nearest known ligand 0.68

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 19/20 0.68
AXL P30530 17/20 0.65
MET P08581 1/20 0.59
TYRO3 Q06418 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27366041 0.89 AXL (0.73) MERTKAXLTYRO3
SCHEMBL27366451 0.84 MERTK (0.63) MERTKAXLMETTYRO3
SCHEMBL1898042 0.82 MERTK (0.80) MERTK
SCHEMBL27365616 0.81 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365619 0.80 MERTK (0.85) MERTKAXLTYRO3
SCHEMBL721300 0.80 AXL (0.62) MERTKAXLMETTYRO3
SCHEMBL27365552 0.79 MERTK (0.65) MERTKAXLMETTYRO3
SCHEMBL27366138 0.79 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27366132 0.79 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL2478035 0.79 MET (0.68) MERTKAXLMETTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed