Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | OGA | O60502 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12874467 | 0.84 | GPR119 (0.61) | GPR119KCNH2OGAOPRK1DHFR | |
| SCHEMBL27363472 | 0.83 | GPR119 (0.55) | GPR119KCNH2OGADHFRCHRNB2 | |
| SCHEMBL890101 | 0.79 | OGA (0.55) | GPR119OGAHRH3DHFRPTPN11 | |
| SCHEMBL24126289 | 0.76 | GPR119 (0.47) | GPR119KCNH2OGAACACBOPRK1 | |
| SCHEMBL12523970 | 0.73 | GPR119 (0.50) | GPR119KCNH2OGADHFR | |
| SCHEMBL83122 | 0.73 | OGA (0.50) | GPR119OGAHRH3DHFRPTPN11 | |
| SCHEMBL22794068 | 0.73 | OGA (0.33) | GPR119OGAHRH3ACACB | |
| SCHEMBL24827892 | 0.73 | ACACB (0.35) | KCNH2OGAHRH3ACACB | |
| SCHEMBL356595 | 0.72 | GPR119 (0.49) | GPR119KCNH2OGADHFR | |
| SCHEMBL13587921 | 0.72 | GPR119 (0.49) | GPR119KCNH2OGAHRH3DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |