Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12874467 | 0.88 | GPR119 (0.61) | GPR119KCNH2HRH4HTR3ACHRNB2 | |
| SCHEMBL27363075 | 0.86 | CHRNA7 (0.43) | GPR119KCNH2SLC6A9HRH4HTR3A | |
| SCHEMBL22737347 | 0.86 | CHRNA7 (0.43) | GPR119KCNH2SLC6A9HRH4HTR3A | |
| SCHEMBL27367017 | 0.83 | GPR119 (0.51) | GPR119KCNH2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL12523970 | 0.77 | GPR119 (0.50) | GPR119KCNH2DHFROGA | |
| SCHEMBL81909 | 0.76 | HRH4 (0.51) | GPR119HRH4HTR3ADHFROGA | |
| SCHEMBL356595 | 0.75 | GPR119 (0.49) | GPR119KCNH2SLC6A9DHFROGA | |
| SCHEMBL13587921 | 0.75 | GPR119 (0.49) | GPR119KCNH2HTR3ADHFROGA | |
| SCHEMBL27364869 | 0.73 | DHFR (0.39) | GPR119DHFROGA | |
| SCHEMBL3614451 | 0.73 | GPR119 (0.71) | GPR119KCNH2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |