Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 4/20 | 0.50 |
| ▸ | LATS2 | Q9NRM7 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.40 |
| ▸ | PRKCA | P17252 | 3/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.40 |
| ▸ | PRKCH | P24723 | 3/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27692880 | 0.86 | LATS1 (0.47) | LATS1LATS2CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL15826710 | 0.76 | LATS1 (0.55) | LATS1LATS2CYP1A2PRKCDPRKCA | |
| SCHEMBL4479184 | 0.76 | CYP2A6 (0.55) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL22970835 | 0.75 | CDK2 (0.39) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10266549 | 0.74 | LATS1 (0.47) | LATS1LATS2CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL29889740 | 0.74 | KDM4E (0.38) | LMNAKDM4EHSD17B10MAPTHTT | |
| SCHEMBL7751472 | 0.74 | CYP2A6 (0.57) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5524176 | 0.73 | KDR (0.56) | LATS1NFKB1 | |
| SCHEMBL25857289 | 0.72 | LATS1 (0.41) | LATS1LATS2CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL8297790 | 0.72 | WNT3A (0.41) | CYP1A2LMNAKDM4EHSD17B10WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310389-B1 | HETEROCYCLES AS PROTEIN KINASE INHIBITORS | AMGEN INC (US) | 2012-01-04 | — | — | EP | disclosed |