SCHEMBL27367032

SCHEMBL27367032

Cc1c(C(=O)Nc2ccc(Oc3ncnc4oc(-c5cnn(C)c5)c(-c5cccc(N)c5)c34)cc2)c(=O)n(-c2ccc(F)cc2)n1C

nearest known ligand 0.77

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 20/20 0.77
AXL P30530 19/20 0.77
TYRO3 Q06418 3/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31512150 1.00 MERTK (0.77) MERTKAXLTYRO3
SCHEMBL27367033 0.92 MERTK (0.77) MERTKAXLTYRO3
SCHEMBL27366943 0.90 MERTK (0.82) MERTKAXLTYRO3
SCHEMBL31512157 0.89 MERTK (0.83) MERTKAXLTYRO3
SCHEMBL27366372 0.89 MERTK (0.83) MERTKAXLTYRO3
SCHEMBL27366301 0.88 MERTK (0.81) MERTKAXLTYRO3
SCHEMBL31512153 0.87 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365620 0.87 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365700 0.86 MERTK (0.80) MERTKAXLTYRO3
SCHEMBL27367182 0.85 MERTK (0.73) MERTKAXLTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070911-A1 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RES INST (TW) 2026-03-12 US disclosed
CN-119968372-A TAM receptor inhibitors 台湾卫生研究院 2025-05-09 CN disclosed
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070911-A1 INHIBITORS OF TAM RECEPTORS CNR1, MSR1, HCAR1 MERTK 246/4885AXL 272/4885TYRO3 227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.