SCHEMBL27367180

SCHEMBL27367180

CN(C)Cc1cccc(-c2c[nH]c3ncnc(Oc4ccc(NC(=O)c5cn(C)n(-c6ccc(F)cc6)c5=O)cc4)c23)c1

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AXL P30530 18/20 0.57
MERTK Q12866 17/20 0.57
TYRO3 Q06418 4/20 0.57
UBE2N P61088 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27367111 0.88 AXL (0.55) AXLMERTKTYRO3UBE2N
SCHEMBL32685072 0.88 MERTK (0.67) AXLMERTKTYRO3
SCHEMBL27366537 0.88 MERTK (0.67) AXLMERTKTYRO3
SCHEMBL27367037 0.82 MERTK (0.83) AXLMERTKTYRO3
SCHEMBL27367242 0.81 MERTK (0.50) AXLMERTKTYRO3
SCHEMBL27367177 0.77 MERTK (0.76) AXLMERTKTYRO3
SCHEMBL27365767 0.77 MERTK (0.66) AXLMERTKTYRO3
SCHEMBL27366549 0.76 MERTK (0.67) AXLMERTKTYRO3
SCHEMBL27365768 0.76 MERTK (0.65) AXLMERTKTYRO3
SCHEMBL27365552 0.76 MERTK (0.65) AXLMERTKTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed