Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.39 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30710513 | 1.00 | LMNA (0.50) | LMNAHPGDPIN1CNR1MAPT | |
| SCHEMBL30959689 | 0.85 | PIN1 (0.46) | LMNAHPGDPIN1CNR1MAPT | |
| SCHEMBL30959691 | 0.85 | PIN1 (0.46) | LMNAHPGDPIN1CNR1MAPT | |
| SCHEMBL27192975 | 0.80 | MAPT (0.47) | LMNAHPGDPIN1CNR1MAPT | |
| SCHEMBL30710449 | 0.78 | NPSR1 (0.47) | HPGDALDH1A1CYP1A2SMN1; SMN2L3MBTL1 | |
| SCHEMBL6888463 | 0.78 | NPSR1 (0.47) | HPGDALDH1A1CYP1A2SMN1; SMN2L3MBTL1 | |
| SCHEMBL30745057 | 0.76 | LMNA (0.54) | LMNAHPGDPIN1MAPTTDP1 | |
| SCHEMBL30688568 | 0.75 | MAPT (0.55) | LMNAHPGDMAPTTDP1USP2 | |
| SCHEMBL5583628 | 0.75 | HPGD (0.60) | LMNAHPGDMAPTUSP2ALDH1A1 | |
| SCHEMBL6372744 | 0.74 | HPGD (0.52) | LMNAHPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250439-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |
| WO-2023250439-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |