SCHEMBL27368417

SCHEMBL27368417

CCOC(=O)/C(=C/c1cc(OC)c(Br)cc1OC)CC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.44
MAPT P10636 4/20 0.44
MEN1 O00255 1/20 0.44
PLIN1 O60240 1/20 0.44
POLB P06746 1/20 0.44
PLIN5 Q00G26 1/20 0.44
KMT2A Q03164 1/20 0.44
ABHD5 Q8WTS1 1/20 0.44
HPGD P15428 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
PKM P14618 2/20 0.42
RAB9A P51151 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
ALDH1A1 P00352 8/20 0.41
KDM4E B2RXH2 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
CYP2C19 P33261 2/20 0.40
CYP3A4 P08684 1/20 0.40
PRKDC P78527 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29279594 1.00 LMNA (0.44) LMNAMAPTMEN1PLIN1POLB
SCHEMBL29814894 0.86 LMNA (0.46) LMNAMAPTMEN1PLIN1POLB
SCHEMBL27002115 0.85 PRKDC (0.42) LMNAMAPTHPGDSMN1; SMN2ALDH1A1
SCHEMBL29279528 0.85 PRKDC (0.42) LMNAMAPTHPGDSMN1; SMN2ALDH1A1
SCHEMBL31456053 0.80 ALDH1A1 (0.47) LMNAMAPTMEN1PLIN1POLB
SCHEMBL31456060 0.80 ALDH1A1 (0.47) LMNAMAPTMEN1PLIN1POLB
SCHEMBL6486687 0.77 MEN1 (0.45) LMNAMAPTMEN1PLIN1POLB
SCHEMBL6486683 0.77 MEN1 (0.45) LMNAMAPTMEN1PLIN1POLB
SCHEMBL11160234 0.74 MAPT (0.66) LMNAMAPTMEN1PLIN1POLB
SCHEMBL10395152 0.73 LMNA (0.41) LMNAMAPTMEN1PLIN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024059090-A1 PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME GILGAMESH PHARMACEUTICALS, INC. (US) 2024-03-21 WO disclosed
WO-2024059017-A2 PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME GILGAMESH PHARMACEUTICALS, INC. (US) 2024-03-21 WO disclosed
EP-4305019-A1 PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME Gilgamesh Pharmaceuticals, Inc. (US) 2024-01-17 EP disclosed
WO-2022192781-A1 PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME GILGAMESH PHARMACEUTICALS, INC. (US) 2022-09-15 WO disclosed