Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.56 |
| ▸ | TPH1 | P17752 | 2/20 | 0.43 |
| ▸ | KYNU | Q16719 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25356410 | 0.72 | GRIA2 (0.81) | GRIA2TPH1KDM4ECYP3A4ALOX15 | |
| SCHEMBL31688735 | 0.72 | GRIA2 (0.81) | GRIA2TPH1KDM4ECYP3A4ALOX15 | |
| SCHEMBL25356408 | 0.72 | GRIA2 (0.81) | GRIA2TPH1KDM4ECYP3A4ALOX15 | |
| SCHEMBL31688759 | 0.71 | GRIA2 (0.65) | GRIA2TPH1KDM4EALOX15HSD17B10 | |
| SCHEMBL6422740 | 0.69 | GRIA1 (0.49) | GRIA2KDM4EALDH1A1LMNACYP3A4 | |
| SCHEMBL28677794 | 0.69 | GRIA2 (0.55) | GRIA2KDM4EALDH1A1LMNACYP3A4 | |
| SCHEMBL28677792 | 0.69 | GRIA2 (0.55) | GRIA2KDM4EALDH1A1LMNACYP3A4 | |
| SCHEMBL4356402 | 0.69 | GRIA2 (0.82) | GRIA2KDM4EALOX15HSD17B10ADORA3 | |
| SCHEMBL13537526 | 0.69 | GRIA2 (0.82) | GRIA2KDM4EALOX15HSD17B10ADORA3 | |
| SCHEMBL22721343 | 0.69 | GRIA2 (0.82) | GRIA2KDM4EALOX15HSD17B10ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056837-C | 5-arylisoxazol-4-yl-substituted 2-aminocarboxylic acid compounds | LUNDBECK & CO AS H (DK) | 2000-09-27 | — | — | CN | disclosed |
| CN-1136810-A | 5-arylisoxazol-4-yl-substituted 2-aminocarboxylic acid compounds | LUNDBECK & CO AS H (DK) | 1996-11-27 | — | — | CN | disclosed |