Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.49 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101768 | 0.81 | PTPRA (0.37) | GRIA1GRIA3GRIA2GRIA4CYP2C9 | |
| SCHEMBL9182148 | 0.71 | GRIA1 (0.46) | GRIA1GRIA3GRIA2GRIA4MAPT | |
| SCHEMBL1262878 | 0.70 | NPSR1 (0.50) | MAPTALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL10279027 | 0.69 | — | — | |
| SCHEMBL27369375 | 0.69 | GRIA2 (0.56) | GRIA2MAPTUSP2CYP2C9MEN1 | |
| SCHEMBL4628266 | 0.69 | CPB2 (0.56) | GRIA1GRIA3GRIA2GRIA4MAPT | |
| SCHEMBL13957557 | 0.69 | GRIA1 (0.48) | GRIA1GRIA3GRIA2GRIA4MAPT | |
| SCHEMBL2267003 | 0.69 | GRIA1 (0.48) | GRIA1GRIA3GRIA2GRIA4MAPT | |
| SCHEMBL28741574 | 0.69 | GRIA1 (0.48) | GRIA1GRIA3GRIA2GRIA4MAPT | |
| SCHEMBL8812980 | 0.68 | GRIA1 (0.71) | GRIA1GRIA3GRIA2GRIA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1308317-C | New fluorinated benzothiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2007-04-04 | — | — | CN | disclosed |
| EP-1557412-A1 | Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators | Les Laboratoires Servier (FR) | 2005-07-27 | — | — | EP | disclosed |
| EP-0840731-B1 | POLYCYCLIC ALCALOID-DERIVATIVES AS NMDA-RECEPTOR ANTAGONISTS | SHIRE BIOCHEM INC (CA) | 2001-10-10 | — | — | EP | disclosed |
| US-5990104-A | INHIBITING NMDA RECEPTOR ACTIVATION BY ADMINISTERING DERIVATIVES OF GIVEN FORMULA, SUCH AS 5,6,7,8,9,11,12-HEPTAHYDRO-3-HYDROXY-5-METHYL-10-THIA-5,11 -METHANOBENZOCYCLODECEN-13-AMINE (SULPHAZOCINE) | BIOCHEM PHARMA, INC. (CA) | 1999-11-23 | — | — | US | disclosed |
| US-5955493-A | Thiamorphinans with neuroprotective activity | BIOCHEM PHARMA, INC. (CA) | 1999-09-21 | — | — | US | disclosed |
| EP-0858333-A1 | THIAMORPHINANS WITH NEUROPROTECTIVE ACTIVITY | BIOCHEM PHARMA INC (CA) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997016183-A1 | THIAMORPHINANS WITH NEUROPROTECTIVE ACTIVITY | BIOCHEM PHARMA INC. (CA) | 1997-05-09 | — | — | WO | disclosed |