Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24666096 | 0.85 | FFAR1 (0.39) | DHODHFFAR1SLC13A5POLBMAPT | |
| SCHEMBL26202197 | 0.85 | HPGD (0.33) | DHODHFFAR1SLC13A5POLBMAPT | |
| SCHEMBL26202199 | 0.85 | S1PR1 (0.36) | DHODHFFAR1SLC13A5POLBMAPT | |
| SCHEMBL12218007 | 0.84 | PTGS2 (0.36) | FFAR1PTGS2NOS3NOS1NOS2 | |
| SCHEMBL24666082 | 0.82 | AAK1 (0.34) | FFAR1AAK1 | |
| SCHEMBL24208476 | 0.80 | PTGS2 (0.38) | FFAR1PTGS2MAPTAAK1L3MBTL1 | |
| SCHEMBL19446283 | 0.80 | SMN1; SMN2 (0.39) | DHODHPTGS2POLBMAPTMAPK1 | |
| SCHEMBL16388761 | 0.79 | NOS3 (0.45) | NOS3NOS1NOS2SLC13A5PKM | |
| SCHEMBL19673294 | 0.79 | BRD4 (0.39) | LRRK2 | |
| SCHEMBL10433762 | 0.78 | NQO1 (0.41) | MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059665-A1 | DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |