Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.43 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19160331 | 0.74 | TP53 (0.50) | CYP1A2CYP3A4CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL28878337 | 0.74 | ALDH1A1 (0.55) | CYP1A2CYP3A4CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL4761586 | 0.74 | CA12 (0.49) | CYP1A2CYP3A4CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL27369170 | 0.72 | CYP2C19 (0.40) | CYP2C19CA12CA1CA2CA9 | |
| SCHEMBL1564273 | 0.72 | CA12 (0.47) | CYP1A2CYP3A4CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL28196405 | 0.72 | CYP11B1 (0.53) | CYP1A2CYP3A4CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL28125757 | 0.71 | CYP19A1 (0.46) | CYP1A2CYP3A4CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL21534 | 0.70 | CA12 (0.48) | CA12CA2CA9TSHRCHRM2 | |
| SCHEMBL8529536 | 0.70 | CA12 (0.48) | CA12CA2CA9TSHRCHRM2 | |
| SCHEMBL27351462 | 0.69 | CA12 (0.42) | CYP1A2CYP3A4CYP2D6CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053188-C | Quinolizinone type compounds | ABBOTT LAB (US) | 2000-06-07 | — | — | CN | disclosed |
| CN-1137273-A | Quinolizinone type compounds | ABBOTT LAB (US) | 1996-12-04 | — | — | CN | disclosed |