SCHEMBL27375177

SCHEMBL27375177

Cc1c(F)ccnc1NN

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CCNE1 P24864 1/20 0.35
CDK2 P24941 1/20 0.35
NOS3 P29474 3/20 0.34
NOS2 P35228 3/20 0.34
LRRK2 Q5S007 1/20 0.33
MAPT P10636 3/20 0.31
ALDH1A1 P00352 2/20 0.31
ADORA3 P0DMS8 1/20 0.31
MAOA P21397 1/20 0.31
PTGS1 P23219 1/20 0.31
OPRM1 P35372 1/20 0.31
KCNH2 Q12809 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
NOS1 P29475 1/20 0.30
KMT2A Q03164 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24457917 0.81 KDM4E (0.40) CCNE1CDK2NOS3NOS2LRRK2
SCHEMBL6385162 0.78 NOS2 (0.52) CCNE1CDK2NOS3NOS2MAPT
SCHEMBL13562936 0.76 LRRK2 (0.46) LRRK2MAPTL3MBTL1KDM4EMEN1
SCHEMBL14691453 0.75 NOS2 (0.39) CCNE1CDK2NOS3NOS2MAPT
SCHEMBL21713526 0.75 NOS3 (0.34) NOS3NOS2LRRK2MAPTALDH1A1
SCHEMBL21713631 0.75 NOS3 (0.34) NOS3NOS2MAPTALDH1A1ADORA3
SCHEMBL19791981 0.71
SCHEMBL16256884 0.70
SCHEMBL15835692 0.70
SCHEMBL1619392 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1053792-A Herbicidal compound with triazolopyridine group RHONE POULENO AGROCHIMIE (FR) 1991-08-14 CN disclosed