SCHEMBL27376274

SCHEMBL27376274

C[Si]1(C)CCN(c2cc(NS(=O)(=O)CCO)ccc2C(=O)Nc2ccnc(N3CCC(F)(F)CC3)c2)CC1

nearest known ligand 0.83

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30717027 1.00 KIF18A (0.83) KIF18A
SCHEMBL29370639 0.91 KIF18A (1.00) KIF18A
SCHEMBL22148704 0.91 KIF18A (1.00) KIF18A
SCHEMBL30717058 0.89 KIF18A (0.66) KIF18A
SCHEMBL27376350 0.89 KIF18A (0.66) KIF18A
SCHEMBL24815885 0.88 KIF18A (0.83) KIF18A
SCHEMBL27376105 0.86 KIF18A (0.82) KIF18A
SCHEMBL30717031 0.86 KIF18A (0.82) KIF18A
SCHEMBL27375643 0.85 KIF18A (0.83) KIF18A
SCHEMBL30717140 0.85 KIF18A (0.83) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039829-A1 INHIBITORS OF KIF18A AND USES THEREOF ACCENT THERAPEUTICS, INC. (US) 2024-02-22 — — WO disclosed
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