Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27383538 | 0.88 | LMNA (0.58) | MAPTLMNAPTGER3ALDH1A1THRB | |
| SCHEMBL30799147 | 0.86 | PTGER3 (0.53) | MAPTLMNAPTGER3ALDH1A1KDM4E | |
| SCHEMBL27383799 | 0.84 | LMNA (0.51) | MAPTLMNAPTGER3ALDH1A1THRB | |
| SCHEMBL27383789 | 0.84 | LMNA (0.51) | MAPTLMNAPTGER3ALDH1A1THRB | |
| SCHEMBL16199218 | 0.80 | LMNA (0.70) | MAPTLMNAPTGER3ALDH1A1THRB | |
| SCHEMBL27383530 | 0.77 | MAPT (0.65) | MAPTLMNAPTGER3 | |
| SCHEMBL27383547 | 0.76 | POLB (0.54) | MAPTLMNAPTGER3THRB | |
| SCHEMBL14324139 | 0.74 | LMNA (0.57) | MAPTLMNAPTGER3ALDH1A1P2RX7 | |
| SCHEMBL30799035 | 0.73 | LMNA (0.47) | MAPTLMNAPTGER3ALDH1A1THRB | |
| SCHEMBL27383548 | 0.71 | LMNA (0.51) | MAPTLMNAALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |