Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.56 |
| ▸ | SRC | P12931 | 9/20 | 0.51 |
| ▸ | INSR | P06213 | 5/20 | 0.51 |
| ▸ | LYN | P07948 | 4/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | LATS1 | O95835 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.51 |
| ▸ | FECH | P22830 | 1/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.51 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.51 |
| ▸ | STK4 | Q13043 | 1/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.51 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27378709 | 0.88 | PIK3CD (0.63) | IGF1RSRCINSRLYNRET | |
| SCHEMBL27399946 | 0.79 | PIK3CD (0.66) | IGF1RSRCINSRLYNRET | |
| SCHEMBL12438496 | 0.76 | IGF1R (0.73) | IGF1RSRCINSRLYNROCK2 | |
| SCHEMBL12438699 | 0.76 | IGF1R (0.75) | IGF1RSRCINSRLYNROCK2 | |
| SCHEMBL14050381 | 0.76 | IGF1R (0.72) | IGF1RSRCINSRLYNROCK2 | |
| SCHEMBL27535239 | 0.75 | SRC (0.58) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL15109623 | 0.74 | IGF1R (0.70) | IGF1RSRCINSRLYNROCK2 | |
| SCHEMBL11411928 | 0.74 | IGF1R (0.78) | IGF1RSRCINSRLYNROCK2 | |
| SCHEMBL4823035 | 0.74 | IGF1R (0.76) | IGF1RSRCINSRLYNROCK2 | |
| SCHEMBL4823041 | 0.74 | IGF1R (0.76) | IGF1RSRCINSRLYNROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1079796-C | Novel N-7-heterocyclyl-pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 2002-02-27 | — | — | CN | disclosed |
| CN-1216544-A | Novel N-7-heterocyclyl pyrrolo [2,3-D] pyridines and their use | NOVARTIS AG (CH) | 1999-05-12 | — | — | CN | disclosed |