Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.63 |
| ▸ | PRKDC | P78527 | 1/20 | 0.63 |
| ▸ | SRC | P12931 | 14/20 | 0.55 |
| ▸ | ABL1 | P00519 | 12/20 | 0.55 |
| ▸ | EGFR | P00533 | 11/20 | 0.55 |
| ▸ | ABL2 | P42684 | 11/20 | 0.55 |
| ▸ | LCK | P06239 | 5/20 | 0.55 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | KIF5B | P33176 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | NPM1 | P06748 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27399946 | 0.91 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL27383576 | 0.88 | IGF1R (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL407936 | 0.79 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL27535239 | 0.75 | SRC (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL27381319 | 0.73 | SRC (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL27512441 | 0.73 | SRC (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL27382297 | 0.72 | SRC (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL7016560 | 0.71 | ABL1 (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGSRC | |
| SCHEMBL12856370 | 0.71 | EGFR (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL7021411 | 0.70 | ABL1 (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1079796-C | Novel N-7-heterocyclyl-pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 2002-02-27 | — | — | CN | disclosed |
| CN-1216544-A | Novel N-7-heterocyclyl pyrrolo [2,3-D] pyridines and their use | NOVARTIS AG (CH) | 1999-05-12 | — | — | CN | disclosed |