Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.58 |
| ▸ | EGFR | P00533 | 7/20 | 0.56 |
| ▸ | ABL1 | P00519 | 6/20 | 0.56 |
| ▸ | ABL2 | P42684 | 6/20 | 0.56 |
| ▸ | KDR | P35968 | 8/20 | 0.53 |
| ▸ | TEK | Q02763 | 6/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27512441 | 0.90 | SRC (0.53) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL27381319 | 0.80 | SRC (0.53) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL27399946 | 0.77 | PIK3CD (0.66) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL27555108 | 0.76 | TEK (0.74) | SRCEGFRKDRTEKLCK | |
| SCHEMBL30136499 | 0.76 | SRC (0.61) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL27378709 | 0.75 | PIK3CD (0.63) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL27383576 | 0.75 | IGF1R (0.56) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL8820310 | 0.74 | EGFR (0.78) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL8819225 | 0.72 | EGFR (0.72) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL15576330 | 0.71 | SRC (0.68) | SRCEGFRABL1ABL2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1079796-C | Novel N-7-heterocyclyl-pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 2002-02-27 | — | — | CN | disclosed |
| CN-1216544-A | Novel N-7-heterocyclyl pyrrolo [2,3-D] pyridines and their use | NOVARTIS AG (CH) | 1999-05-12 | — | — | CN | disclosed |