Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.38 |
| ▸ | AKT2 | P31751 | 3/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 5/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2739260 | 1.00 | AKT1 (0.38) | AKT1AKT2AKT3MAPK1SFRP1 | |
| SCHEMBL684421 | 0.89 | AKT1 (0.40) | AKT1AKT2AKT3MAPK1PDE2A | |
| SCHEMBL12188343 | 0.89 | AKT1 (0.40) | AKT1AKT2AKT3MAPK1PDE2A | |
| SCHEMBL680793 | 0.87 | EPHX2 (0.41) | AKT1AKT2AKT3MAPK1PDE2A | |
| SCHEMBL681291 | 0.87 | EPHX2 (0.41) | AKT1AKT2AKT3MAPK1PDE2A | |
| SCHEMBL2738567 | 0.85 | MC4R (0.41) | AKT1AKT2AKT3MAPK1PDE2A | |
| SCHEMBL2738568 | 0.85 | MC4R (0.41) | AKT1AKT2AKT3MAPK1PDE2A | |
| SCHEMBL17030316 | 0.84 | PDE2A (0.35) | PDE2AEPHX1KCNH2 | |
| SCHEMBL2739268 | 0.84 | AKT1 (0.41) | AKT1AKT2AKT3RPS6KB1AURKB | |
| SCHEMBL10258343 | 0.84 | GRM2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966065-A2 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |