Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738649 | 0.84 | AKT1 (0.38) | PDE2AKCNH2EPHX1 | |
| SCHEMBL2739260 | 0.84 | AKT1 (0.38) | PDE2AKCNH2EPHX1 | |
| SCHEMBL2739268 | 0.82 | AKT1 (0.41) | GRM2ALDH1A1KDM4E | |
| SCHEMBL2739269 | 0.82 | AKT1 (0.41) | GRM2ALDH1A1KDM4E | |
| SCHEMBL10258343 | 0.82 | GRM2 (0.35) | GRM2ALDH1A1KCNA3OPRM1KDM4E | |
| SCHEMBL12292976 | 0.82 | HTR2A (0.35) | GRM2HTR2AHTR2CKCNA3OPRM1 | |
| SCHEMBL2738791 | 0.82 | PDE2A (0.43) | PDE2A | |
| SCHEMBL2738777 | 0.76 | TACR2 (0.47) | ALDH1A1SLC6A3KDM4E | |
| SCHEMBL681291 | 0.74 | EPHX2 (0.41) | PDE2A | |
| SCHEMBL680793 | 0.74 | EPHX2 (0.41) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402325-B1 | Hydroxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2015-08-26 | — | — | EP | disclosed |