Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | USP14 | P54578 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL684378 | 0.88 | PAX8 (0.40) | KCNA3HSD11B1OPRM1KDM4EUSP14 | |
| SCHEMBL680805 | 0.86 | HSD11B1 (0.37) | KCNA3HSD11B1OPRM1KDM4EALDH1A1 | |
| SCHEMBL2739269 | 0.86 | AKT1 (0.41) | GRM2KDM4EALDH1A1POLB | |
| SCHEMBL12292976 | 0.86 | HTR2A (0.35) | GRM2KCNA3HSD11B1OPRM1TERT | |
| SCHEMBL2739268 | 0.86 | AKT1 (0.41) | GRM2KDM4EALDH1A1POLB | |
| SCHEMBL2738649 | 0.84 | AKT1 (0.38) | — | |
| SCHEMBL2739260 | 0.84 | AKT1 (0.38) | — | |
| SCHEMBL2738529 | 0.82 | SLC18A3 (0.44) | KCNA3HSD11B1KDM4ESLC18A3ALDH1A1 | |
| SCHEMBL17030316 | 0.82 | PDE2A (0.35) | GRM2KCNA3OPRM1KDM4EALDH1A1 | |
| SCHEMBL2738791 | 0.81 | PDE2A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966065-A2 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |