SCHEMBL27388016

SCHEMBL27388016

Cc1ccc(-c2cccc3c2oc2c(-c4ccccc4)cccc23)cc1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.47
ADORA3 P0DMS8 1/20 0.41
ADORA2A P29274 1/20 0.41
ADORA1 P30542 1/20 0.41
PRKDC P78527 6/20 0.41
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 3/20 0.40
PIK3CD O00329 3/20 0.40
PIK3CA P42336 3/20 0.40
PIK3CB P42338 3/20 0.40
PIK3CG P48736 3/20 0.40
BRD4 O60885 2/20 0.40
BRD2 P25440 2/20 0.40
BRD3 Q15059 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
PDE2A O00408 1/20 0.40
PIK3C2A O00443 1/20 0.40
PIK3R2 O00459 1/20 0.40
PIK3C2B O00750 1/20 0.40
PDE5A O76074 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27387929 0.86 ALOX5 (0.64) ALOX5PRKDCALDH1A1PIK3CDPIK3CB
SCHEMBL12968446 0.83 SMN1; SMN2 (0.49) ALOX5ADORA1PRKDCALDH1A1KDM4E
SCHEMBL9917225 0.83 ADORA3 (0.49) ALOX5ADORA3ADORA2AADORA1PRKDC
SCHEMBL9917224 0.83 NPC1 (0.47) ALOX5ADORA3PRKDCALDH1A1KDM4E
SCHEMBL19802294 0.83 ALOX5 (0.46) ALOX5ADORA3ADORA2AADORA1PRKDC
SCHEMBL22151549 0.82 ALOX5 (0.49) ALOX5PRKDCALDH1A1KDM4EPIK3CD
SCHEMBL11713826 0.82 PRKDC (0.47) ALOX5PRKDCALDH1A1KDM4EPIK3CD
SCHEMBL23989064 0.82 PRKDC (0.46) ALOX5ADORA3ADORA2AADORA1PRKDC
SCHEMBL27387933 0.82 GLA (0.46) ALOX5ADORA3ADORA2AADORA1PRKDC
SCHEMBL19011080 0.82 ALOX5 (0.59) ALOX5ADORA3ADORA2AADORA1PRKDC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024126322-A1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2024-06-20 WO disclosed