Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738810 | 0.88 | CHRM2 (0.46) | CHRM2CYP3A4HTR1AADRA2ACHRM1 | |
| SCHEMBL2738809 | 0.87 | CHRM2 (0.49) | CHRM2CYP3A4HTR1AADRA2ACHRM1 | |
| SCHEMBL2738813 | 0.85 | CHRM2 (0.46) | CHRM2CYP3A4HTR1AADRA2ACHRM1 | |
| SCHEMBL2738885 | 0.82 | CHRM2 (0.63) | CHRM2CYP3A4KCNH2CYP2D6SLC22A1 | |
| SCHEMBL2738811 | 0.81 | CHRM2 (0.48) | CHRM2CYP3A4HTR1AADRA2ACHRM1 | |
| SCHEMBL218014 | 0.79 | CHRM2 (0.46) | CHRM2CYP3A4HTR1AADRA2ACHRM1 | |
| Chlorphenoxamine SCHEMBL29208 | 0.77 | CHRM2 (0.61) | CHRM2CYP3A4HTR1AADRA2ACHRM1 | |
| Chlorphenoxamine SCHEMBL125112 | 0.76 | CHRM2 (0.59) | CHRM2CYP3A4HTR1AADRA2ACHRM1 | |
| Chlorphenoxamine SCHEMBL1649036 | 0.75 | CHRM2 (0.62) | CHRM2CYP3A4HTR1AADRA2ACHRM1 | |
| SCHEMBL10733508 | 0.73 | CHRM2 (0.61) | CHRM2CYP3A4HTR1AADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |