Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.40 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.40 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738867 | 0.87 | CXCL8 (0.43) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL2738870 | 0.85 | CXCL8 (0.41) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL220500 | 0.85 | CXCL8 (0.46) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL2738868 | 0.81 | CXCL8 (0.45) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL220262 | 0.79 | PTGS2 (0.43) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL10123705 | 0.72 | CXCL8 (0.49) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL18484662 | 0.72 | CXCL8 (0.49) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL20369286 | 0.70 | CXCL8 (0.47) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL10878786 | 0.70 | CXCL8 (0.47) | CXCL8PTGS2TTRAKR1B10UGT1A9 | |
| SCHEMBL10108588 | 0.69 | CXCL8 (0.46) | CXCL8PTGS2TTRAKR1B10UGT1A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |
| EP-1778252-A2 | NONCARDIOTOXIC PHARMACEUTICAL COMPOUNDS | Barbeau, Donald L. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020573-A2 | NONCARDIOTOXIC PHARMACEUTICAL COMPOUNDS | BARBEAU DONALD L (US) | 2006-02-23 | — | — | WO | disclosed |