Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971029 | 1.00 | CYP2C19 (0.47) | CYP2C19CYP2C9SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL12188588 | 0.88 | ACACB (0.48) | CYP2C19CYP2C9SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL14950914 | 0.88 | ACACB (0.48) | CYP2C19CYP2C9SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL13323474 | 0.88 | ACACB (0.48) | CYP2C19CYP2C9SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL2033051 | 0.84 | CA2 (0.51) | CA2ACACBKMT2APPARGPPARA | |
| SCHEMBL805208 | 0.84 | CA2 (0.51) | CA2ACACBKMT2APPARGPPARA | |
| SCHEMBL4303242 | 0.84 | CA2 (0.51) | CA2ACACBKMT2APPARGPPARA | |
| SCHEMBL23960332 | 0.84 | ACE (0.51) | SLC6A2CA2 | |
| SCHEMBL9886029 | 0.84 | TDP1 (0.43) | ACACBPPARGEPHX1 | |
| SCHEMBL12118463 | 0.84 | ACE (0.51) | SLC6A2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |