Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18511375 | 1.00 | DPP4 (0.48) | DPP4DPP7SLC7A5PTGS1KDM4E | |
| SCHEMBL18492879 | 1.00 | DPP4 (0.48) | DPP4DPP7SLC7A5PTGS1KDM4E | |
| SCHEMBL29481457 | 0.86 | SLC7A5 (0.62) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL1613644 | 0.86 | SLC7A5 (0.62) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL29478416 | 0.86 | SLC7A5 (0.62) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL18511382 | 0.86 | SLC7A5 (0.62) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL44052 | 0.86 | SLC7A5 (0.62) | SLC7A5PTGS1KDM4EUSP2EGFR | |
| SCHEMBL12104028 | 0.86 | DPP4 (0.48) | DPP4DPP7SLC7A5PTGS1KDM4E | |
| SCHEMBL14355719 | 0.86 | DPP4 (0.48) | DPP4DPP7SLC7A5PTGS1KDM4E | |
| SCHEMBL44051 | 0.86 | SLC7A5 (0.62) | SLC7A5PTGS1KDM4EUSP2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |
| EP-2049500-B1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2008006032-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |