Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16433937 | 0.86 | S1PR1 (0.47) | JAK2S1PR1CDK4CCNE1CDK2 | |
| SCHEMBL22130327 | 0.78 | JAK2 (0.55) | JAK2CDK4CCNE1CDK2COMT | |
| SCHEMBL327670 | 0.77 | ALOX5 (0.54) | JAK2CDK4CCNE1CDK2COMT | |
| SCHEMBL7813078 | 0.75 | PTGS1 (0.42) | JAK2S1PR1CDK4CCNE1CDK2 | |
| SCHEMBL2833977 | 0.75 | PTGS1 (0.42) | JAK2S1PR1CDK4CCNE1CDK2 | |
| SCHEMBL320589 | 0.74 | PTGS2 (0.54) | JAK2CDK4CCNE1CDK2COMT | |
| SCHEMBL12362816 | 0.74 | ALOX5 (0.52) | JAK2CDK4CCNE1CDK2COMT | |
| SCHEMBL327283 | 0.74 | PTGS1 (0.53) | JAK2S1PR1CDK4CCNE1CDK2 | |
| SCHEMBL12943444 | 0.74 | PTGS2 (0.53) | JAK2CDK4CCNE1CDK2COMT | |
| SCHEMBL92933 | 0.74 | ALOX5 (0.66) | JAK2CDK4CDK2COMTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137742-A1 | COMPOUNDS AND COMPOSITIONS AS FGFR3 DEGRADERS AND USES THEREOF | BLUEPRINT MEDICINES CORPORATION (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024137742-A1 | COMPOUNDS AND COMPOSITIONS AS FGFR3 DEGRADERS AND USES THEREOF | BLUEPRINT MEDICINES CORPORATION (US) | 2024-06-27 | — | — | WO | disclosed |