SCHEMBL27399286

SCHEMBL27399286

COC(=O)C(NC(=O)c1ccc2ncc(Br)n2c1)C(=O)OC

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.35
SCN10A Q9Y5Y9 1/20 0.35
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
RAB9A P51151 2/20 0.34
NPC1 O15118 1/20 0.34
TP53 P04637 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
TGFBR1 P36897 1/20 0.34
PIK3CA P42336 1/20 0.34
CLK1 P49759 3/20 0.33
GAA P10253 2/20 0.33
TRIM24 O15164 1/20 0.33
TRIM33 Q9UPN9 1/20 0.33
RIPK2 O43353 1/20 0.33
EPHB3 P54753 1/20 0.33
GLA P06280 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19950862 0.80 ATM (0.44) KDM4ESCN10AALDH1A1HPGDSMN1; SMN2
SCHEMBL3033347 0.80 MAPK1 (0.45) KDM4EALDH1A1RAB9ANPC1TGFBR1
SCHEMBL19950854 0.73 KDM4E (0.49) KDM4ESCN10AALDH1A1HPGDTP53
SCHEMBL29229590 0.72 KDM4E (0.36) KDM4ESCN10AALDH1A1HPGDRAB9A
SCHEMBL2119966 0.72 CA12 (0.54) ALDH1A1HPGDRAB9ASMN1; SMN2RXFP1
SCHEMBL19950919 0.72 IRAK4 (0.45) KDM4EALDH1A1HPGDSMN1; SMN2TGFBR1
SCHEMBL25149588 0.71 KDM4E (0.54) KDM4ESCN10AALDH1A1HPGDRAB9A
SCHEMBL25148907 0.71 P4HTM (0.50) KDM4ESCN10AALDH1A1HPGDRAB9A
SCHEMBL31051308 0.69 DGAT1 (0.49) KDM4EALDH1A1HPGDRAB9ANPC1
SCHEMBL31051303 0.67 LMNA (0.52) KDM4EALDH1A1HPGDRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4634178-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES Syngenta Crop Protection AG (CH) 2025-10-22 EP disclosed
WO-2024126404-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-06-20 WO disclosed
WO-2024126404-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-06-20 WO disclosed