Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 3/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27381632 | 1.00 | CA2 (0.45) | CA2MAPK1CA1GPR84FFAR1 | |
| SCHEMBL27473530 | 0.98 | CA2 (0.46) | CA2MAPK1CA1GPR84FFAR1 | |
| SCHEMBL27345960 | 0.91 | CA2 (0.54) | CA2MAPK1CA1FDPS | |
| SCHEMBL18100109 | 0.91 | CA2 (0.48) | CA2GPR84FFAR1LMNAGRIK1 | |
| SCHEMBL11762017 | 0.84 | CA2 (0.47) | CA2MAPK1CA1GPR84FFAR1 | |
| SCHEMBL5933413 | 0.81 | CA2 (0.48) | CA2MAPK1CA1GPR84FFAR1 | |
| SCHEMBL10995430 | 0.81 | CA2 (0.48) | CA2MAPK1CA1GPR84FFAR1 | |
| SCHEMBL10496961 | 0.81 | CA2 (0.48) | CA2MAPK1CA1GPR84FFAR1 | |
| SCHEMBL15674875 | 0.81 | CA2 (0.48) | CA2MAPK1CA1GPR84FFAR1 | |
| SCHEMBL28334022 | 0.80 | CA2 (0.52) | CA2MAPK1CA1LMNAGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1077886-C | Amidino derivatives useful as nitric oxide synthase inhibitors | SEARLE & CO (US) | 2002-01-16 | — | — | CN | disclosed |
| CN-1137268-A | Amidino derivatives useful as nitric oxide synthase inhibitors | SEARLE & CO (US) | 1996-12-04 | — | — | CN | disclosed |