Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22655993 | 0.77 | CES2 (0.45) | RIPK1AKR1C3AKR1C2CES2CES1 | |
| SCHEMBL31691805 | 0.77 | CES2 (0.45) | RIPK1AKR1C3AKR1C2CES2CES1 | |
| SCHEMBL27403256 | 0.77 | HTT (0.46) | AKR1C3AKR1C2CES2CES1L3MBTL1 | |
| SCHEMBL19859415 | 0.71 | GCGR (0.36) | RIPK1PRKCECES2CES1MEP1B | |
| SCHEMBL18722844 | 0.69 | PRKCE (0.34) | PRKCETDP1PDK2 | |
| SCHEMBL19859261 | 0.69 | PRKCE (0.34) | PRKCEMEP1BTDP1PDK2 | |
| SCHEMBL582370 | 0.68 | RET (0.44) | PRKCERETPOLBTDP1L3MBTL1 | |
| SCHEMBL20333718 | 0.68 | RIPK1 (0.43) | RIPK1AKR1C3AKR1C2CES2CES1 | |
| SCHEMBL19859156 | 0.67 | CYP3A4 (0.36) | PRKCEMEP1BPOLBTDP1 | |
| SCHEMBL12585680 | 0.66 | CES2 (0.43) | RIPK1AKR1C3AKR1C2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145245-A2 | ALPHA-V-BETA-8 INTEGRIN INHIBITORS AND USES THEREOF | PLIANT THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |