Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.68 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 7/20 | 0.51 |
| ▸ | ACHE | P22303 | 7/20 | 0.49 |
| ▸ | BCHE | P06276 | 4/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27377633 | 0.92 | TNF (0.57) | TNFNOD1NPC1GALR3LMNA | |
| SCHEMBL5128515 | 0.84 | APP (0.51) | TNFNOD1NPC1RAB9AAPP | |
| SCHEMBL5128296 | 0.83 | NPC1 (0.53) | TNFNOD1NPC1GALR3NR2F2 | |
| SCHEMBL27655477 | 0.82 | TNF (0.44) | TNFNOD1RAB9AAPPPDE5A | |
| SCHEMBL7404118 | 0.81 | TNF (1.00) | TNFNOD1NPC1GALR3LMNA | |
| SCHEMBL5123734 | 0.81 | APP (0.48) | TNFNOD1NPC1RAB9AAPP | |
| SCHEMBL5123492 | 0.80 | ESR1 (0.67) | TNFNOD1APPSTAT1PDE5A | |
| SCHEMBL5120111 | 0.79 | ACHE (0.47) | TNFNOD1NPC1RAB9AAPP | |
| SCHEMBL3121034 | 0.79 | APP (0.79) | APPACHEBCHESTAT1MEN1 | |
| Hydrochloric Acid SCHEMBL3123789 | 0.78 | APP (0.77) | APPACHEBCHESTAT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875023-A | Use of thienopyrimidines | MERCK PATENT GMBH (DE) | 2006-12-06 | — | — | CN | disclosed |
| CN-1081638-C | Thienopyrimidine compounds | MERCK PATENT GMBH (DE) | 2002-03-27 | — | — | CN | disclosed |
| CN-1227560-A | Thienopyrimidines | MERCK PATENT GMBH (DE) | 1999-09-01 | — | — | CN | disclosed |