Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 6/20 | 0.42 |
| ▸ | USP1 | O94782 | 2/20 | 0.42 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27377633 | 0.86 | TNF (0.57) | TNFNOD1PDE5ARAB9A | |
| SCHEMBL27403243 | 0.83 | PDE5A (0.44) | TNFNOD1PDE5A | |
| SCHEMBL15440490 | 0.82 | PDE5A (0.62) | ESR1USP1WDR48PDE5AAPP | |
| SCHEMBL27403244 | 0.82 | TNF (0.68) | TNFNOD1PDE5AAPPRAB9A | |
| SCHEMBL5130194 | 0.82 | USP1 (0.44) | ESR1USP1WDR48PDE5AAPP | |
| SCHEMBL5123979 | 0.80 | ESR1 (0.43) | ESR1USP1WDR48PDE5AAPP | |
| SCHEMBL5118432 | 0.78 | ICAM1 (0.48) | ESR1USP1WDR48PDE5AAPP | |
| SCHEMBL5127810 | 0.77 | USP1 (0.50) | ESR1USP1WDR48PDE5AAPP | |
| SCHEMBL5128688 | 0.76 | ESR1 (0.72) | ESR1 | |
| SCHEMBL25306105 | 0.76 | APP (0.74) | USP1WDR48PDE5AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875023-A | Use of thienopyrimidines | MERCK PATENT GMBH (DE) | 2006-12-06 | — | — | CN | disclosed |