Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clonidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.32 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.32 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clonidine SCHEMBL5982 | 0.94 | MAPT (0.36) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL1369983 | 0.94 | MAPT (0.36) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL3974275 | 0.92 | ADRA2A (0.36) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL9838987 | 0.92 | MAPT (0.35) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL22127030 | 0.92 | MAPT (0.35) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL40751 | 0.92 | ADRA2A (0.36) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL10972183 | 0.92 | ADRA2A (0.36) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL1172959 | 0.92 | ADRA2A (0.36) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL22127029 | 0.90 | MAPT (0.34) | MAPTHSP90AA1DYRK3CSNK1ECLK1 | |
| Clonidine SCHEMBL1369066 | 0.90 | MAPT (0.34) | MAPTHSP90AA1DYRK3CSNK1ECLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1085532-C | Medicine for giving up medicinal dependence | HEBEI AQUATIC PRODUCT INST (CN) | 2002-05-29 | — | — | CN | disclosed |
| CN-1227102-A | Medicine for giving up medicinal dependence | HEBEI PROV AQUATIC PRODUCT INS (CN) | 1999-09-01 | — | — | CN | disclosed |