Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of 4-Nitroaniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Nitroaniline SCHEMBL22394765 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KMT2AMAPTMEN1PKM | |
| 4-Nitroaniline SCHEMBL11298826 | 0.88 | ALDH1A1 (0.82) | ALDH1A1KMT2AMAPTMEN1PKM | |
| 4-Nitroaniline SCHEMBL27986521 | 0.86 | ALDH1A1 (0.78) | ALDH1A1KMT2AMAPTMEN1PKM | |
| Nitrobenzene SCHEMBL27986256 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1TDP1LOXL2 | |
| 4-Nitroaniline SCHEMBL28656726 | 0.84 | ALDH1A1 (0.75) | ALDH1A1KMT2AMAPTMEN1PKM | |
| 4-Nitroaniline SCHEMBL1900089 | 0.84 | ALDH1A1 (0.75) | ALDH1A1KMT2AMAPTMEN1PKM | |
| Sebacic Acid SCHEMBL11821874 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KMT2AMAPTMEN1PKM | |
| SCHEMBL9065915 | 0.83 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1PKM | |
| 4-Nitroaniline SCHEMBL13529022 | 0.83 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1PKM | |
| 4-Nitroaniline SCHEMBL16451 | 0.83 | ALDH1A1 (1.00) | ALDH1A1KMT2AMAPTMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116925181-B | Application of oyster active peptide in preparing antidiabetic medicament | 广东海洋大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-116925181-A | Application of oyster active peptide in preparing antidiabetic medicament | 广东海洋大学 | 2023-10-24 | — | — | CN | disclosed |
| CN-116064285-B | Lactobacillus rhamnosus ZJUIDS07 capable of reducing blood sugar and application thereof | 浙江大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-115998838-B | Composition with blood sugar reducing synergistic effect and application thereof | 广东海洋大学 | 2023-08-08 | — | — | CN | disclosed |
| CN-116064285-A | Lactobacillus rhamnosus ZJUIDS07 capable of reducing blood sugar and application thereof | 浙江大学 | 2023-05-05 | — | — | CN | disclosed |
| CN-115998838-A | Composition with blood sugar reducing synergistic effect and application thereof | 广东海洋大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-113462613-B | Lactobacillus plantarum ZJUIDS04 capable of reducing blood sugar and application thereof | 浙江大学 | 2022-03-22 | — | — | CN | disclosed |
| CN-113528383-B | Hypoglycemic lactobacillus ZJUIDS09 and application thereof | 浙江大学 | 2022-03-22 | — | — | CN | disclosed |
| CN-113528383-A | Hypoglycemic lactobacillus ZJUIDS09 and application thereof | 浙江大学 | 2021-10-22 | — | — | CN | disclosed |
| CN-113462613-A | Lactobacillus plantarum ZJUIDS04 capable of reducing blood sugar and application thereof | 浙江大学 | 2021-10-01 | — | — | CN | disclosed |
| CN-1083112-A | A kind of method for determining bacteria and equipment | HE LIN (CN) | 1994-03-02 | — | — | CN | disclosed |