Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22040486 | 0.88 | SMPD3 (0.60) | SMPD3LOXL2ECE1ALDH1A1PTGDR2 | |
| SCHEMBL27409981 | 0.85 | POLB (0.50) | SMPD3LOXL2ALDH1A1PTGDR2PDPK1 | |
| SCHEMBL8234511 | 0.82 | PTGDR2 (0.52) | SMPD3LOXL2ECE1PTGDR2HCRTR1 | |
| SCHEMBL22000048 | 0.81 | SMPD3 (0.56) | SMPD3LOXL2ECE1PTGDR2PDPK1 | |
| SCHEMBL8078437 | 0.81 | SMPD3 (0.52) | SMPD3LOXL2ECE1ALDH1A1PTGDR2 | |
| SCHEMBL1068648 | 0.80 | LOXL2 (0.55) | SMPD3LOXL2ALDH1A1PTGDR2PDPK1 | |
| SCHEMBL3247666 | 0.79 | LOXL2 (0.50) | SMPD3LOXL2ALDH1A1PDPK1HDAC2 | |
| SCHEMBL15010747 | 0.78 | SMPD3 (0.60) | SMPD3LOXL2ECE1PTGDR2HCRTR1 | |
| SCHEMBL29291643 | 0.78 | SMPD3 (0.52) | SMPD3ECE1ALDH1A1PTGDR2PDPK1 | |
| SCHEMBL7054724 | 0.78 | SMPD3 (0.52) | SMPD3ECE1ALDH1A1PTGDR2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260108527-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS INC (US) | 2026-04-23 | — | — | US | disclosed |
| EP-4598912-A1 | POLO LIKE KINASE 4 INHIBITORS | Oric Pharmaceuticals, Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076891-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| WO-2024076891-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260108527-A1 | POLO LIKE KINASE 4 INHIBITORS | PLK4, PLK2, PLK3 | SMPD3 1955/4885LOXL2 1257/4885ECE1 4538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.