Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 4/20 | 0.38 |
| ▸ | TMPRSS4 | Q9NRS4 | 4/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.35 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27410045 | 0.85 | ALOX5AP (0.33) | HSP90AA1 | |
| SCHEMBL27523064 | 0.80 | P2RX1 (0.38) | P2RX1TMPRSS4P2RX4P2RX7HIF1A | |
| SCHEMBL27537513 | 0.73 | P2RX1 (0.38) | P2RX1TMPRSS4P2RX4P2RX7HIF1A | |
| SCHEMBL27411545 | 0.71 | RPS6KB1 (0.31) | MEN1HTTKMT2A | |
| SCHEMBL27505400 | 0.71 | BIRC5 (0.41) | P2RX1TMPRSS4P2RX4P2RX7CYP3A4 | |
| SCHEMBL27489605 | 0.71 | TMPRSS4 (0.39) | P2RX1TMPRSS4P2RX4P2RX7CYP3A4 | |
| SCHEMBL5754718 | 0.69 | COMT (0.42) | P2RX1TMPRSS4P2RX4P2RX7CYP3A4 | |
| SCHEMBL27412369 | 0.69 | PDE3B (0.34) | P2RX1 | |
| SCHEMBL6130145 | 0.68 | P2RX1 (0.41) | P2RX1TMPRSS4P2RX4P2RX7HIF1A | |
| SCHEMBL5752911 | 0.67 | KMT2A (0.41) | P2RX1TMPRSS4P2RX4P2RX7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1226803-A | Diphenyl heterocycles as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 1999-08-25 | — | — | CN | claimed |
| CN-1116287-C | Diphenyl heterocycles as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2003-07-30 | — | — | CN | disclosed |
| CN-1226803-A | Diphenyl heterocycles as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 1999-08-25 | — | — | CN | disclosed |