Indole

Indole

SCHEMBL27416652

Oc1ccccc1Cl.c1ccc2[nH]ccc2c1

nearest known ligand 0.63

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 4/20 0.63
TRPA1 O75762 1/20 0.63
CA1 P00915 1/20 0.63
CA2 P00918 1/20 0.63
ITGB2 P05107 1/20 0.63
ICAM1 P05362 1/20 0.63
ITGAL P20701 1/20 0.63
CA4 P22748 1/20 0.63
CA6 P23280 1/20 0.63
ADK P55263 1/20 0.63
ALDH1A1 P00352 2/20 0.56
MAOB P27338 4/20 0.43
MAOA P21397 3/20 0.43
CMA1 P23946 1/20 0.41
F7 P08709 1/20 0.41
LTA4H P09960 1/20 0.41
F3 P13726 1/20 0.41
NR4A2 P43354 1/20 0.41
TYR P14679 1/20 0.41
USP2 O75604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indole SCHEMBL8976398 0.88 AHR (0.57) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL3268691 0.86 AHR (0.77) AHRTRPA1CA1CA2ITGB2
2,6-Dichlorophenol SCHEMBL28901498 0.85 AHR (0.63) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL6386255 0.80 AHR (0.90) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL1160186 0.79 AHR (1.00) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL698 0.79
Indole SCHEMBL30463845 0.79
Indole SCHEMBL29352896 0.79
Indole SCHEMBL30250492 0.79
Indole SCHEMBL28071644 0.79 AHR (1.00) AHRTRPA1CA1CA2ITGB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1089086-C Luminandide medicine MILLS RANDELL L (US) 2002-08-14 CN claimed