Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL225078 | 0.95 | PSMB1 (0.40) | ESR1ESR2KDR | |
| SCHEMBL227135 | 0.85 | PSMB1 (0.53) | ESR1ESR2 | |
| SCHEMBL228619 | 0.79 | LTA4H (0.48) | ESR1ESR2 | |
| SCHEMBL227379 | 0.79 | PSMB1 (0.49) | ESR1ESR2KDR | |
| SCHEMBL225638 | 0.78 | PSMB1 (0.53) | ESR1ESR2 | |
| SCHEMBL2741690 | 0.77 | LTA4H (0.50) | ESR1ESR2KDR | |
| SCHEMBL8708988 | 0.73 | ESR1 (0.67) | ESR1ESR2 | |
| SCHEMBL225413 | 0.70 | LTA4H (0.55) | — | |
| SCHEMBL3092657 | 0.68 | ESR1 (0.65) | ESR1ESR2 | |
| SCHEMBL7116068 | 0.68 | ESR1 (0.65) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399520-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-8399520-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | RADIUS HEALTH, INC. | 2012-01-05 | — | — | US | disclosed |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | RADIUS HEALTH, INC. | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | ESR1, GPER1, ESR2 | ESR1 1/4885ESR2 3/4885KDR 884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.