Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.49 |
| ▸ | JAK1 | P23458 | 13/20 | 0.49 |
| ▸ | TYK2 | P29597 | 7/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27417191 | 0.91 | JAK3 (0.49) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27414691 | 0.90 | JAK3 (0.58) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27293389 | 0.90 | NPSR1 (0.42) | JAK3JAK1TYK2SYKUSP2 | |
| SCHEMBL29232009 | 0.89 | JAK1 (0.53) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL29883088 | 0.89 | JAK1 (0.53) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27417586 | 0.87 | JAK3 (0.49) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27417045 | 0.85 | JAK3 (0.52) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27419078 | 0.85 | JAK3 (0.50) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27294058 | 0.84 | TYK2 (0.55) | JAK1TYK2CDK2CDK9USP2 | |
| SCHEMBL27293280 | 0.83 | SYK (0.41) | JAK3JAK1TYK2SYKUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4637738-A2 | INHIBITORS OF JAK2 | Llydaw Therapeutics, Inc. (US) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024137548-A2 | INHIBITORS OF JAK2 | Llydaw Therapeutics, Inc. (US) | 2024-06-27 | — | — | WO | disclosed |